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KMID : 0385219920020020095
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Korean Journal of Gerontology
1992 Volume.2 No. 2 p.95 ~ p.102
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Effect of Dietary Vitamin E on Biochemical Composition of Male Rats in Carbon Tetrachloride-Induced Hepatotoxicity
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Huh Rhin-Sou
Choi Yeon-Shik
Do Jae-Cheul
Jung Jung-Won
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Abstract
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Vitamin E( -tocopherol) is chiefly localized in the cellular membrane in vivo and is an oldest cellular antioxidant. It relates to various metabolisms of th lipid, protein and enzyme activity, etc. Especially this plays important roles in scavenging the free radical by the nonenzymatic reaction and inhibiting the formation and accumulation of the lipid peroxidant. Vitamin E is also known to act as the aging inhibitor in vivo. The present study was conducted to investigate th effect of dietary vitamin E on biochemical compositions in carbon tetrachloride-intoxicated male rats. The results obtained were summarized as follows; 1. The change of body weight was remarkably reduced by CCl4 and vitamin E administration inhibits the reduction of body weight 2. The albumin content in serum was significantly decreased(p<0.01) by CCL4 and was significantly increased(p<0.01) by vitamin E administration. The total bilirubin content in serum was significantly increased(p<0.01) in contrast with the control group and was very significantly decreased(p<0.01) by vitamin E administration. 3. The cholesterol content in serum was significantly increased(p<0.01) by CCl4 and was significantly decreased(p<0.01) by CCL4 and was significantly increased(p<0.01) by vitamin E administration. 4. The glycogen contents in liver was significantly decreased(p<0.01) by CCl4 and was significantly increased(p<0.01) by vitamin E administration. 5. The contents of unsaturated fatty acids conjugated in phospholipids in liver was significantly decreased(p<0.01) in contrast with the control group and was significantly increased(p<0.01) by vitamin E administration. 6. The content of maolndialdehyde, lipid peroxide in liver was significantly increased(p<0.01) by CCl4 and was significantly decreased(p<0.01) by vitamin E administration. From these results, vitamin E seems to have the promoting effect on repairing hepatic damage by inhibiting the lipid peroxidation process maintained by free radical, lipid peroxide of CCl4 in body.
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KEYWORD
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vitamin E, CCl4, lipid peroxidation, hepatoprotective effect
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